Dichlorofluoroacetic acid

In the Utell et al. (1997) study, urine samples were collected prior to exposure, at the end of exposure (0-4 h), and at 4-12 h and 12-24 h for measurement of metabolites (Tong et al. 1998). The major metabolite was 2,2-dichloro-2-fluoroethyl glucuronide. Excretion of the metabolite was dose-dependent with the highest amounts present in the 4-12 h urine samples. A small amount of dichlorofluoroacetic acid was present. HCFC-141b was not detected in blood 24 h after exposure. 

Sodium dichlorofluoroacetate is prepared by neutralization of dichlorofluoroacetic acid in ether wilh sodium carbonate, with subsequent removal of ether and water under reduced pressure followed by heating at 50° (4 mm.) overnight. Lithium dichlorofluoroacetate Can be prepared in the same way. 

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