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Dibromides reaction with dialkyl cuprates

Double substitution of geminal dibromides is best accomplished by treatment with an organocuprate, followed by the addition of an alkyl iodide to the crude reaction mixture. " The reaction has found especial application for the synthesis of dimethylcyclopropanes, ubiquitous in natural product chemistry. Excellent yields are often obtained with Me2CuLi, but with less reactive substrates higher order cyano-and thiocyano-cuprates sometimes provide better results. Spiro dialkylation of geminal dibromides has also been accomplished. Vicinal dibromides, on the other hand, afford alkenes upon treatment with dialkyl cuprates. ... [Pg.216]


See other pages where Dibromides reaction with dialkyl cuprates is mentioned: [Pg.539]    [Pg.601]    [Pg.1401]   
See also in sourсe #XX -- [ Pg.3 , Pg.216 ]

See also in sourсe #XX -- [ Pg.216 ]

See also in sourсe #XX -- [ Pg.3 , Pg.216 ]




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Cuprate, 3- -, reaction with

Dialkyls with

Dibromide

Dibromides

With cuprates

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