Dibenzo acridine

Dibenzo[a,/r ] acridine, Benzo [a] acridine, and Benzo[c]acridine... 

Figure 7. Structure and numbering of dibenzo[a,h]acridine and its major metabolites. Figure adaptedfrom reference 27.

Figure 8. Epoxide ring opening reactions of bay-region diol epoxides and epoxides from dibenzo[a,h] acridine, and epoxides from benzo[a]acridine and benzo[c]acridine. Figure adaptedfrom reference 27. 

Figure 10. Epoxide ring opening reactions of the fluor mated derivatives of dibenzo [a,h] acridine-1,2-epoxide. Figure adapted from reference 27.

Ullmann and Fetvadjian reported the modification which made the synthesis more generally useful, when they heated together equimolar amounts of an aromatic amine and a phenol with paraformaldehyde or with benzaldehyde, thus making it possible to obtain unsymmetrical acridines (03CB1027). Thus, from 2-naphthol and 1-naphthylamine they obtained dibenzo[c,/]acridine (613), and from 2-naphthol and 2-naphthylamine dibenzo[c,fi]acridine (614). In a similar manner, from 1-aminoacridine and the two naph-thols are obtained the benzo [a]- and benzo[c]-naphtho[2,3-fi]acridines (615) and (616), and from 2-aminoacridine and the naphthols the benzo[a]- and benzo[c]-naphtho[2,3-/]acridines (617) and (618) (69JCS(C)1337). The isomeric benzofa]- and benzo[c]-... 

The unstable dibenz[c,/][l,2]oxazepines (312 R = CN, Cl) have been isolated as the major products of the UV irradiation of 9-cyano- and 9-chloro-acridine 10-oxides (310) in benzene (c/. the analogous Af-imide to 1,2-diazepine conversion on p. 598). Although none of the oxaziridine tautomer (311) was detectable by UV spectroscopy, the subsequent deoxygenation of (312) to acridine suggests the existence of a thermal equilibrium between (311) and (312) (79T1273). These dibenzo compounds (312) are the only fully unsaturated oxazepines yet isolated but the 2,3-benzoxazepin-l-one system (314) has recently been prepared by the reaction of benzonitrile oxide with the benzopyranone (313) (80JCS(Pl)846). 

ACRIDINE Dibenzo [ b,e] Pyridine, lti-Azaanthracene, Benzo(b)-Qni noline Poison, III NL NL NL ... 

Table III summarizes experimental and theoretical data on the first three absorption bands (Lb, La, Bb) in the spectra of pyridine, quinoline, isoquinoline, acridine, and their benzo and dibenzo derivatives.

Nitrofluorene Dibenzo[a,j)acridine 4-Amino-trans-stilbene... 

Aktivierte Hetarene reagieren mit Phosphorigsaure-trialkylestern in Acetonitril bei 25° in Gegenwart von Natriumjodid. So erhalt man z.B. in hohen Ausbeuten 5,10-Dihydro-acridin-10-, bzw. 1 OH- (Dibenzo[b e ]pyran)-10- sowie 10H-(Dibenzo[b e thiopyran)-10-phosphonsdure-diethylester444 ... 

DIBENZCARBAZOLE see DCYOOO DIBENZENECHRO UM see BGY700 DIBENZENECHROMIUM IODIDE see BGY720 DIBENZHEPTROPINE see EAGIOO DIBENZHEPTROPINE CITRATE see EAGIOO DIBENZO(a,j)ACRIDINE see DCS600... 

The reaction between Fe3(CO)i2 and naphthacene lead to a new type of binuclear complex (CieHi2)[Fe2(CO)e] for which structure (XXIII) was proposed 22). The condensed aromatics acridine, phenazine, 4-benz[c]acridine, 5-benzo[a]phenazine, and dibenzo[a,c]phenazine were shown to react with Fe3(CO)ia to give complexes in which an Fe(CO)3 moiety is bound to a terminal ring directly adjacent to the heterocycle ring 22). 

The reduction of dibenzo[a,j]acridine by sodium in liquid ammonia yields a complex mixture of which the 7,14-dihydro derivative is a key product. 

H-dibenzo[c,g]carbazole, dibenz[a,j]acridine and benzo(a)pyrene in mouse skin. Cancer Lett 37 337-344. 

Depending on the ring fusion, pyridoacridines can be classified into the following main classes pyrido[a]acridines (benzo[ ]phenanthrolines), pyrido[b]acridines, pyrido[c]acridines (benzo[h]phenanthrolines), and pyr-ido[k/]acridines (dibenzo[/,i/][2,7]naphthyridines). 

The analysis of azaarenes, some of which such as dibenz [a, ] acridine, dibenzfa,// ]acridine, and 7H-dibenzo[c,y]carbazole are suspected carcinogens, has been discussed in detail (Herod 1998). 

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