Pulmonary hypertension diazoxide

Direct vascular smooth-muscle relaxants evaluated in primary pulmonary hypertension include hydralazine, isosorbide dinitrate, and diazoxide. In general, the hemodynamic effects of these drugs include modest reduction in mean pulmonary artery pressure, which parallels a significant reduction in systemic arterial pressure, decreased pulmonary vascular resistance, and increased cardiac output. 

Multioi an damage An infant with persistent hyperinsulinemic hypoglycemia received diazoxide and developed pulmonary hypertension, heart failure, and neutropenia [119 ]. 

A girl with macrosomia, who was deUvered by cesarean section at 34 weeks, developed seizures and hypoglycemia in the first days of Ufe due to hyperinsuhnemia and was given octreotide and diazoxide. After 10 days she became short of breath with signs of heart failure and had evidence of pulmonary hypertension on echocardiography and cardiac catheterization. There was also neutropenia. Her respiratory... 

Diazoxide is a potent vasodilator chemically resembling the thiazides, but it is not a diuretic. Diazoxide can be administered both parenterally and orally. Caution has been stressed when diazoxide is administered as an intravenous bolus into the pulmonary artery because the solution is highly alkaline (pH 11.6) and irritating to vascular tissue (Cotter and Honey, 1980). In one study with chronic oral diazoxide administration (300-600 mg/day), five of seven patients had important side effects including diabetes mellitus, fluid retention, nausea, vomiting, and postural hypertension that required discontinuation of the drug (Wise, 1983). 

---