Diazomalonic acid

Diazoindene, 3116 Diazomalonic acid, 1081 Diazomalononitrile, 1344 Diazomethane, 0406 5-(Diazomethylazo)tetrazole, 0719 Diazomethyldimethylarsine, 1240... 

Citronellic acid, 3352 Cyanoacetic acid, 1113 Diazirine-3,3-dicarboxylic acid, 1080 Diazomalonic acid, 1081... 

Diazoindene, 3110 Diazomalonic acid, 1078 Diazomalononitrile, 1340 Diazomethane, 0405 5-(Diazomethylazo)tetrazole, 0715 Diazomethyldimethylarsine, 1236 3-Diazopropene, 1132 a-Diazo-y-thiobutyrolactone, 1430 Di-terf-butyl diazomalonate, 3405 Dicyclopropyldiazomethane, 2820 Dideuterodiazomethane, 0335 Diethyl diazomalonate, 2824 Dinitrodiazomethane, 0542... 

Citronellic acid, 3346 Cyanoacetic acid, 1110 Diazirine-3,3-dicarboxylic acid, 1077 Diazomalonic acid, 1078... 

Thep-nitrophenyl ester of diazomalonic acid has been made. While this derivative proved useful for acylating the serine residues at the active sites of trypsin and chymotrypsin (e.g. Vaughan and Westheimer, 1969a,b ... 

Photolytic and catalytic decomposition of a-diazo esters produces )8-lactones, which are formed via intramolecular C—H insertion of a carbene or carbenoids. Tertiary alkyl esters of diazomalonic acid are decomposed by rhodium acetate with exclusive formation of the four-membered ring 211. This suggests a smooth insertion into the C—H bond activated by the adjacent oxygen atom (90TL1023). jS-Lactone 212 was obtained by photolysis of diazo malonic ester 213 (71CC577). 

The attempted synthesis of O-bridged compounds from mixed allyl esters of diazomalonic acid of the type 723, in which the olefinic chain is located at the diazo side of the molecule, has failed (93JOC4646). However, tethering the olefin moiety to the chain that links the carbonyl and diazocarbonyl functionalities provides a great variety of tricyclic-nonfused compounds (82T1477 92JA1874 94TL7159). The most representative examples are shown in Schemes 41 and 42. 

Following the method of Corey and Felix [12], Lowe studied the photolysis of the diazomalonic acid amide system. This modification is useful because it provides an ester substituent on the a-carbon of the 0-lactam ring a good target for further synthetic manipulations towards the desired amide substituent. From the first photolytic experiments of this system (114), both the cis (115) and... 

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