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Diazo coupling steric effects

As in the reaction of imidazole, no major isotope effect has been observed 3-deuterioindole reacts at about the same rate as indole. The diazo coupling of five-membered heteroaromatic substrates therefore appears similar to that of homocyclic compounds where, in the absence of steric hindrance, slow attack of the diazonium ion is followed by a fast proton loss.165... [Pg.261]

Write the products of diazo coupling of benzenediazonium chloride with each of the following molecules, (a) Methoxybenzene (b) l-chloro-3-methoxybenzene (c) l-(dimethylamino)-4-(Ll-dimethylethyl)benzene. (Hint Diazo couplings are quite sensitive to steric effects.)... [Pg.1022]


See other pages where Diazo coupling steric effects is mentioned: [Pg.17]    [Pg.789]    [Pg.174]    [Pg.192]    [Pg.110]    [Pg.451]    [Pg.145]    [Pg.381]   
See also in sourсe #XX -- [ Pg.27 ]

See also in sourсe #XX -- [ Pg.27 ]

See also in sourсe #XX -- [ Pg.27 ]




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