1.3- Diazetidine-2,4-diones

Table 6 Normal modes of 1,3-dichloro-1,3-diazetidine-2,4-dione at HF level, DFT level, and MP-2 level of theory assuming a standard 6-311 G basic set...

Table 8 Correction factors and geometric parameters for 1,3-dichloro-1,3-diazetidin-2,4-dione 45...

Diazetidin-2,4-dione has been found to be a chymase inhibitor (IC50 4.0nM). It has been found that 1,3-diazetidin-2,4-dione derivatives possess high activities against bovine pancreatic cr-chrymotrypsin, human cathepsin G, and human neutrophil elastase. Some of the derivatives of l,3-diazetidin-2,4-diones have been shown to be effective as a scaffold for serine protease inhibitors <2001BML1691>. Further, 1,3-diazetidinone containing scaffolds have been found to possess potential antibacterial properties (Section 2.13.7.3). 

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