Diastolic heart failure prognosis

Zile MR, Brutsaert DL. New concepts in diastolic dysfunction and diastolic heart failure Part I diagnosis, prognosis, and measurements of diastolic function. Circulation 2002 105 1387-1393. 

Heart failure (HP) may becausedbya primary abnormality in systolic function, diastolic function, or both. Making the distinction is important because the prevalence, prognosis, and treatment of HP may be quite different depending on whether the predominant mechanism causing the symptoms is systolic or diastolic dysfunction. Some clinical studies have reported that as many as 30% to 50% of patients with congestive heart failure have preserved left ventricular (LV) function, making diastolic heart failure (DHP) very common. In addition, abnormalities in diastolic function also can play an important role in the development of symptoms in patients with cardiomyopathy and systolic heart failure (SHP). 

Zile MR Diastolic heart failure Diagnosis, prognosis, treatment. Minerva Cardiol 2003 51 131-142. 

Diabetes is highly prevalent in the heart failure population, with current estimates indicating that it is present in approximately one-third of heart failure patients. Diabetes may contribute directly to systolic or diastolic dysfunction, as well as indirectly by contributing to the development of coronary artery disease. Diabetes is an independent risk factor for developing heart failure, and its presence is associated with a hastened progression of heart failure and worse prognosis. 

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