Diastolic heart failure pathophysiology

Kitzman DW, Little WC, Brubaker PH, et al. Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure. JAMA 2002 288 2144-2150. 

With a few notable exceptions, many of the drugs used to treat systolic heart failure are in fact the same as those used to treat DHF (Fig. 18-3). However, the rationale for their use, the pathophysiologic process that is being altered by the drug, and the dosing regimen may be entirely different depending on whether the patient has systolic or diastolic... 

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