Diastereofacial selectivity Mannich reaction

Although methods for stereocontrol of the aldol reaction are well documented, including diastereofacial selectivity in reactions of chiral enolates,25 stereocontrol in Mannich reactions appears to have received relatively little attention.26-30... 

Diastereoselective enolate amination as an approach to a-aminoke-tones.42 We have demonstrated that the Mannich reaction is successful for the highly stereoselective introduction of P-aminoketone moieties (vide supra, Asymmetric Mannich Reactions24). The diastereofacially selective electrophilic amination of enolates is attractive as a complementary approach to the asymmetric... 

High diastereofacial selectivity has been observed in asymmetric Mannich reactions of 2-acyl-2-alkyl-l,3-dithiane 1-oxides, leading to P-amino ketones in good yield [118]. This study is of particular significance since stereoselectiAdty in the Mannich reaction has received relatively little attention [119]. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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