2,3 -Diaryl-1 -naphthols,from

Oxygenation by SLO-1 is inhibited by various additives. Some of the reasons are (1) the reduction of active iron from the ferric form to the ferrous form, e,g, by N-alkylhydroxylamine [268], phenyldiazene [269], 2-benzyl-1-naphthol [270], diaryl-N-hydroxyurea [271] (2) oxidation of residues, e.g, methionine residues, by hexanal phenylhydrozone [272] (3) coordination to the active site, e.g. catechol [273], cysteine [274], hydroperoxy acids [275], chelating reagents [276], and Pt complex [277] (4) reaction with the active site, e.g. 12-iodo-ci5-9-octadecenoic acid [278]. In addition, it is reported that leukotriene A4, the electrophilic product of 5-lipoxygenases, irreversibly inactivates the enzyme [279]. 

---