2.6- Diaminopurine riboside

The phosphorylation of adenosine to adenosine-5 -phosphate was demonstrated some time ago in crude yeast extracts. The extracts did not act on guanosine, and no yeast adenylic acid was formed. More recently it has been found that the synthesis involves transfer of phosphate from ATP to adenosine, and the term adenosine phosphoki-nasc has been applied to the enzyme. The activity occurs in yeast maceration juice and in kidney and liver extracts of the rat and rabbit. The enzyme is quite specific, for a partially purified brewers yeast preparation catalyzes the phosphorylation of only two nucleosides out of seventeen which have been tested. The two nucleosides are adenosine itself and 2,6-diaminopurine riboside (2-amino adenosine). The reactions are ... 

Zhou, D. Madej, and E. De Cleicq, Investigations on the anti-HIV activity of 2, 3 -dideoxyadenosine analogues with modifications in either the pentose or purine moiety. Potent and selective anti-HTV activity of 2,6-diaminopurine 2, 3 -dideoxy-riboside, Biochem. Pharmacol. 37 1317 (1988). 

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