2,4-diamino pyrimidine kinase inhibitors

Figure 1.8 A range of 2,4-diamino pyrimidine kinase inhibitors.

Lin R, Johnson S. G, Connolly P. J, Wetter S. K, Binnun E, Hughes T. V, Murray W. V, Pandey N. B, Moreno-Mazza S. J, Adams M, Fuentes-Pesquera A. R, Middleton S. A. Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d] pyrimidine analogues as anti-tumor epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, Bioorg. Med. Chem. Lett. 2009. p. 2333 - 2337. DOI 10.1016/j.bmcl.2009.02.067... 

Synthesis and evaluation of 2,7-diamino-thiazolo[4,5-d]pyrimidines analogs as antitumor EGFR tyrosine kinase inhibitors... 

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