1, 2-Diamino-4-phenylimidazole

It should be noted that a similar reaction indirectly verifying the said mechanism is also found for 1,2-diamino-4-phenylimidazole 148 [125]. The only difference between the two reactions is the fact that in the latter case it is not the nitrogen atom but is the 7i-excessive carbon reaction center that participates in cyclocondensation (Scheme 4.46). Also, subsequent heteroaromatization of the dihydro derivative 150 into imidazopyridine 151 does not require amino-group elimination. 

Diamino-4-phenylimidazole reacts with aromatic a,/3-unsaturated ketones in an acidic medium to yield triazepines 436 (83KGS93). If the reaction is carried out in alkaline medium with benzylidene acetophenone,... 

Oxidation of Schiff bases of the monoamide 8 derived from diamino-maleonitrile gives 4-cyanoimidazole-5-carboxamides (Eq. 4). A new synthesis of 2-formyl-4-methyl-l-phenylimidazole 3-oxide (10) involves the fluoride-ion-promoted cyclization of the trimethylsilyl ether of JV-dichloro-acetyl-A-phenylaminopropanone oxime (9). ... 

V. V. Lipson, N. V. Svetlichnaya, S. V. Shishkina, O. V. Shishkin, Mendeleev Commun. 2(X)8, 18, 141-143. Cascade cyclization of l,2-diamino-4-phenylimidazole with aromatic aldehydes and Meldrum s acid. 

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