Diamine oxidase, human kidney

Diamine oxidase (pig kidney, human pregnancy plasma, pea seedlings) 261 Dihydrolipoyl transacetylase (Escherichia coli)[27] Dipeptidyl carboxypeptidase[281 DNA polymerase-a (human)1291... 

Structure. Diamine oxidases are homo-dimeric enzymes. The subunits weigh between 60 and 105 kD depending upon the organism of origin [114]. Human diamine oxidase from kidneys is composed of 752 amino acid residues, and the corresponding enzyme from rat colon has 747 residues [29]. Diamine oxidases share the TOPA-chinon cofactor with amine oxidases. The ligands of the type 2 copper center in diamine oxidase are possibly the conserved residues Cys 391, Cys 417, and His 510 [29]. 

Diamine oxidase occurs, like amine oxidase, in bacteria, animals, and plants [133]. The comparison of amino acid sequences of the amiloride-binding protein from human kidney, rat colon, diamine oxidase from human placenta, pig kidney, and amine oxidase from Hansenula polymorpha and lentil seeds has shown that the amiloride-binding protein and diamine oxidase are identical proteins[29]. The amiloride-binding protein was previously postulated to function as an epithelial sodium-transporter. While its physiological function is still... 

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