Diam-BINAP

Figure 14 Synthesis of diam-BINAP and poly-BINAP.

Reaction of the hydrobromide of 6,6 -dimethylamino-BINAP (diam-BINAP) with [Ru(T) -2-methylallyl)2(r -COD)] afforded a water soluble Ru-catalyst which proved active and highly enantioselective [209] in the hydrogenation of ethyl acetoacetate (Scheme 3.22). The catalyst could be recycled in the aqueous phase several times. 

Nitrogen-containing phosphines (Figure 15) remain in the center of ligand synthesis. One reason for this may be in the solubility of the (unprotonated) amines in common organic solvents which allows the use of the methods of conventional organic synthesis. An additional aspect is in that amines can be further functionalized by several ways, for example as seen in 2.6 above. Another example is the reaction of 160 (diam-BINAP) with 2,6-tolylene diisocyanate affording an enantiopure polymeric... 

DDAPS diam-BINAP DIOP = seep.78 = 160, see p.35 = /ram-4,5-bis(diphcnylphosphinomethyl>2,2-dimethyl-l,3-dioxolan... 

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