Diacarnus levii

D Ambrosio, M. Guerriero, A. Deharo, E. Debitus, C. Munoz, V. Pietra, F. (1998) New types of potentially antimalarial agents norditerpene and norsesterterpene epidioxides from the marine sponge Diacarnus levii. Helv. Chim. Acta, 81, 1285-92. 

Methyl-3-epinuapapuanoate, (65) [Fig. (25)], a norditerpene derivative isolated from the New Caledonian sponge Diacarnus levii [83], showed in vitro activity against chloroquine-resistant strains of P. falciparum with IC5o = 1.2 pg/mL [84]. When the molecule was tested against P. berghei in vivo, at the concentration of 25 mg/Kg, a 56% growth inhibition was observed. 

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