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Diabetic neuropathy clinical presentation

The prevalence of diabetic neuropathy rises from 7.5% at the time of diagnosis to 50% after 25 years and seems to be directly related to the duration of diabetes. The commonest type is a symmetric sensory and autonomic polyneuropathy. Once symptomatic autonomic neuropathy is present the prognosis for survival is substantially diminished. The clinically silent phase of diabetic nephropathy in Type-II diabetes may last 5-10 years. It is characterized by rising urinary albumin excretion caused by a capillary lesion in the glomerulus. Microalbuminuria varies and can be found in 15-60% of all Type-II diabetics it is defined by an excretion rate between... [Pg.23]

A number of ARIs have reached phase II or III clinical trials but only three are presently in clinical development (Fidorestat, Lidorestat and Ranirestat). In general most studies have been disappointing either due to lack of efficacy or evolvement of severe side effects. Some studies including recent long-term studies have shown effect with moderate to minor improvements in electrophysiological (i.e. 1 m/s in NCV) and symptomatic end points [18,19]. However, ARFs are not presently established as a treatment modality for diabetic neuropathy, and critical factors for success of ARFs in the future will depend on development of non-toxic compounds with sufficient nerve tissue selectivity and affinity to ensure tissue penetration to normalize sorbitol generation in the nerve. [Pg.242]

III. Clinical presentation. Initial symptoms include nausea and vomiting. Occasionally, confusion, stupor, and coma occur after several hours. After a delay of several hours to days, irreversible autonomic neuropathy, peripheral neuropathy, and diabetes may occur. [Pg.361]

You are a supplementary prescriber working in a diabetes clinic when John Stephens comes in to see you. He is still overweight despite being on the maximum dose of metformin and gliclazide. His HbAlc is 9.0% and on examination he has neuropathy developing in his feet. He is also on ramipril 10 mg, simvastatin 40 mg and aspirin 75 mg daily. His blood pressure was 130/80 mmHg and his total cholesterol was 4.0 mmol/L (reading from three months ago). There is no microalbuminuria present. [Pg.141]

Clinical signs of infection in the diabetic foot may not be present secondary to the angiopathy and neuropathy. [Pg.1987]


See other pages where Diabetic neuropathy clinical presentation is mentioned: [Pg.269]    [Pg.270]    [Pg.511]    [Pg.41]    [Pg.34]    [Pg.137]    [Pg.171]    [Pg.3]    [Pg.242]    [Pg.456]    [Pg.897]    [Pg.51]    [Pg.34]   
See also in sourсe #XX -- [ Pg.239 ]




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