Diabetes, biotin vitamin

Long-term regulation of acetyl-CoA carboxylase involves nutritional, hormonal (e.g., insulin, thyroxine), and other factors. In animals on high-carbohydrate diets, fat-free diets, choline deprivation, or vitamin B12 deprivation, the activity is enhanced. However, fasting, high intake of fat or of polyunsaturated fatty acids, and prolonged biotin deficiency leads to decreased activity. In diabetes, the enzyme activity is low, but insulin administration raises it to normal levels. 

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