Diabetes biological significance

Several biologically significant products which are alkaryl glycosides have been synthesised the metabolite (11) of the diabetes therapeutic ciamexon potassium lespedezate (12) which is involved with the circadian rhythm in plants, and salidroside (13). ... 

PTKs have been implicated in the regulation of a variety of biological responses such as cell proliferation, migration, differentiation, and survival. They have been demonstrated to play significant roles in the development of many disease states, including immunodeficiency, atherosclerosis, psoriasis, osteoporosis, diabetes, and cancer. In recent clinical trials impressive antitumor effects of PTK inhibitors have been observed. In future, PTK inhibitors may therefore become important drugs for the treatment of specific cancers. 

The 3-deoxyhexos-2-uloses, which had long been hypothesized as intermediates in many important degradation reactions of carbohydrates, have been isolated and studied,412 in particular, 3-deoxy-D- erythro-hexos-2-ulose 3-deoxyglucosone (206), which is found in higher concentrations in diabetic animals.413 In mammals, a significant proportion of 206 is reduced to form 3-deoxy-D-eryt/ ro-hexos-2-ulose (3-deoxy-D-fructose, 207), which was detected in blood and urine. This conversion is likely to be biologically useful, since 207 would be less reactive, and therefore less damaging than 206. 

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