Diabetes antipsychotic agents

Gianfrancesco F, Grogg A, Mahmoud R, Wang R-H, Meletiche D. Differential effects of antipsychotic agents on the risk of development of type 2 diabetes mellitus in patients with mood disorders. Clin Ther 2003 25 1150-71. 

Antipsychotics can activate retardation or diminish excitation therefore, tranquilizer is a misnomer. These agents do not, in any real sense, produce a state of tranquility in normal or psychotic individuals in fact, normal control subjects often find their effects unpleasant. An appropriate analogy may be aspirin, which reduces an elevated temperature but typically does not alter normal temperature. Another example is insulin, which replaces the absent endogenous supply and restores a diabetic to normal glucostasis. So, too, antipsychotics normalize cognition and behavior. 

A number of drugs should be avoided in HF including antiar-rhythmic agents, calcium channel blockers, antipsychotics, antihistamines, corticosteriods, and nonsteroidal anti-inflammatory drugs. Metformin and thiazolidinediones should be used with caution in HF with diabetes. Trials of statins have generally excluded patients with symptomatic HF but two studies with morbidity and mortality outcomes in HF are now under way. 

Diabetes, hypertension, tranquilizer and treatment of madness (antipsychotic) Diabetes, malaria, pyrexia, pneumonia, anti-inflammatory agent and analgesics, protozoan diseases and insect repellant Good health tonics, stomach troubles, skin problems and diabetes... 

---