Di-3-pyridyl

Therapeutic Function Diagnostic aid (pituitary function) Chemical Name 2-methyl-1,2-di-3-pyridyl-1-propanone Common Name —... 

Two additional examples of the Suzuki coupling using diethyl (3-pyridyl)borane include the coupling with 4-chloro-2,3 -bipyridine l -oxide (40) to give terpyridine 41 [7] and the coupling with 1,8-dibromonaphthalene to afford a mixture of two atropisomers 42 and 43 of l,8-di(3 -pyridyl)naphthalene [33, 34], Interestingly, the N atoms in 42 and 43 provide enough steric and spectral differentiation to make the detection of atropisomers possible at room temperature. 

Several condensation routes to 2,3 -bipyridinones have been reported. Thus 3-acetylpyridine and nicotinaldehyde were condensed to the a,/ -unsat-urated ketone 45, which reacted in a Michael condensation with l-(car-bamoylmethyl)pyridinium chloride (46) to give 2,4-di(3-pyridyl)-6-pyridone (47). Compound 47 was converted to the alkaloid nicotelline 10 by replacement of the hydroxyl group of 47 by chlorine, followed by reductive dehalogenation. Related condensations have been described, including the synthesis of 4,6-diphenyl-2,3 -bipyridine. Similarly, aldehyde 48 was condensed with cyanoacetamide (49) to afford 2-(3-pyridyl)-5-cyano-6-pyridone (50), the cyano group of which was hydrolyzed and decarbox-ylated to 2,3 -bipyridin-6-one. Several modifications and extensions of... 

Phenanthroline is obtained in very low yield (1-2%) by the photocyclization of trans-1,2,-di-(3-pyridyl)ethylene, along with 3,8-and 1,8-phenanthrolines.12... 

Phenanthroline was first claimed to have been synthesized by a double Pomeranz-Fritsch isoquinoline synthesis.11 It has recently been prepared12 in about 12% yield by the irradiation of trans-l,2-di(3-pyridyl)ethylene in benzene, along with 1,8-phenanthroline (12-20%) and 1,10-phenanthroline (1-2%). The melting point is quite different from that recorded earlier by Ruggli and Schetty.11 This latter method has subsequently been used15 to prepare an AT, AT -dimethyl diquaternary salt of 3,8-phenanthroline by methylating the crude product from the irradiation reaction. 

Chemical Name 2-Methyl-l,2-di-3-pyridyl-l-propanone Common Name -Structural Formula ... 

Diarytphenanthrenes. Tetraaryl-l,2-ethanediols are converted to phenan-threne derivatives on exposure to triflic acid. An exception is 1,2-diphenyl-1,2-di(3-pyridyl)ethanediol, which undergoes normal pinacol rearrangement. 

Axial base chelation was similarly used to prepare a symmetric diheme Meso-1,2-di-(3-pyridyl)ethylenediamine (31) was coupled with mesoporphyrin monomethyl ester 32 through the pivaloyl anhydride, followed by iron insertion to give the diheme 33 (Scheme 16). The reaction with CO exhibits two rate constants, indicating either two environments or a sequential change of environment due to cooperativity. 

The non-acidic anti-inflammatory compound 2-isopropyl-3-nicotinylindole (L-8027) inhibits thromboxane biosynthesis [114-116] with simultaneous inhibition of PGE formation, indicating that the compound is not a specific inhibitor of thromboxane synthetase [117]. Metopyrone (2-methyl-l,2-di-3-pyridyl-l-propanone), which shares some structural features with L-8027, was reported to inhibit thromboxane formation in microsomes from human platelets and bovine lung [118]. 

In [ Zn[di(3-pyridyl)viologen]2(MeCN)2 6C104] , one Zn atom is coordinated by four ligands and two acetonitrile molecules, and the opposing pyridyl moieties coordinate to neighboring Zn atoms forming a 2-D sheet-like structure (2-D rhombic grid Scheme 4b). 

Metyrapone, 2-methyl-l,2-di-3-pyridyl-l-pro-panone, is a potent reversible inhibitor (Dominguez and Samuels 1963, Sanzari and Peron 1966, Satre and Vignais 1974) of the and cytochrome P-450iip-hydroxylase enzyme system of the adrenal cortex. A quantitative structure activity relationship has been established between 5-hydro-xytryptamine receptor agonist activity of 8-hydro-xy-2-alkylamino)tetralins and adrenal cortical lip-hydroxylase inhibition potency of metyrapone derivatives and the van der Waals volume of the compound (Singh 1986). 

Di-2-pyridyl ketone, D-70502 Di-3-pyridyl ketone, D-70503 Di-4-pyridyl ketone, D-70504 l//-Indole-3-carboxylic acid Nitrile, A -Ac, in... 

Nicotelline, discovered very early and already assumed to be a terpyridyl at that time (Pictet and Rotschy 1901), indeed turned out to be 2,4-di-(B-pyridyl)-pyridine (= 3",4-pyridyl-2,3 -dipyridyl) (Kufliner and Faded 1956). Congeners of similar, however partially hydrogenated structure, anatalline and anabasamine, respectively, could be isolated from the roots of N. tabacum (Kisaki et al. 1968 Warfield et al. 1972, respectively). Anatalline [2,4-di(3-pyridyl)piperidine] was shown to be accumulated in two isomeric forms, cis and trans, respectively, in N. tabacum cv. by-2 cell cultures (Haekkinen et al. 2004). Anabasamine is also a constituent of Anabasis aphylla (Chenopodiaceae) as can be assumed already from its name (Leete 1983). 

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