Dextrins biological activity

The 5,8-disubstituted indolizidines and 1,4-disubstituted quinolizidines are the more common structural patterns found in amphibian skin[21]. None of these alkaloids has so far been reported from any other source. In addition, the biological activity of only a few 5,8-disubstituted indolizidines has been investigated due to the isolation in minute quantities from the skin. Among them, the relative stereochemistry of quinolizidine 2071 was anticipated to be 75 by our chiral synthesis of 76[35] followed by stereocontrolled synthesis of 75[36]. A sample of synthetic racemate of 75 had produced the best separations on GC analysis with (3-dextrin chiral column[36]. 

Remarkably, the presence in solution of the dmg of I2 molecules and 13 ions affect drug s biological properties such as toxicity, irritation [44, 46]. Selection of equilibrium concentrations of molecular iodine and triiodide can reduce toxicity while retaining antimicrobial properties. The reviewed studies could shed a light on such phenomena. One assumes that involvement of a-dextrins in the mixture ensure the presence of the three active centers located within the a-dextrin helix molecular iodine coordinated lithium halogenides and polypeptides, triiodide and lithium halogenides. We believe that the existence of two complexes of iodine and triiodide reduces toxicity of the dmgs [17-20]. 

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