DEX, Dexamethasone

C, cytarabine ASP, asparaginase CALCB, Cancer and Leukemia Croup B CNS, central nervous system CTX, cyclophosphamide DEX, dexamethasone DNR, daunorubicin DOX, doxorubicin IT, intrathecal captopurine MTX, methotrexate PRED, prednisone TG, thioguanine VCR, vincristine. 

The observed responses are shown as either an increase (f), decrease ( ) or no change (nc) compared to the controls. Dex dexamethasone TAT tyrosine aminotransferase. 

DAS, diallyl sulfide TSO, fraas-stilbene oxide SJW, St. John s wort extract DEX, dexamethasone PCN, pregnenolone- 16a-carbonitrile TCPOBOP, l,4-bis-[2-(3,5-dichloropyridyloxy)]benzene PB, phenobarbital CBZ, carbamazepine CITCO, 6-(4-chlorophenyl)imidazo[2,l-b]thiazole-5-carbaldehyde 0-(3,4-dichlorobenzyl)oxime 2-AAF, 2-acetylaminofluorene. 

Figure 9.1-3 Key in utero immune maturation events and toxicant disruption. Seven in utero critical immune maturation events in the rodent are shown with developmental immunotoxicants known to disrupt those processes. In some cases, the processes are blocked by the xenobiotics while in others the integrity of the process may be compromised by early-life exposure. Arrows are not designed to indicate precise in utero timing but rather general periods of prenatal development. CsA = cyclosporin A CY = cyclophosphamide DEX = dexamethasone EPS = lipopolysaccharide. Adapted from Dietert and Piepenbrink (2006a).

FIGURE 3.5 Sketch of the indirect competition FLISA protocol used for the multiplex determination of drugs in pork tissue samples. DEX, dexamethasone MPA, medroxyprogesterone acetate GM, gentamicin CZP, clonazepam CEF, ceftiofur and dBSA, denatured bovine serum albumin. (Reprinted with permission from Peng, C. et al. 2009. 

FIGURE 2 MEEKC APPI/MS analysis of five steroids. Total ion current (TIC) and extracted ion currents (XIC) of gestrinone (GES), canrenone (CAN), metolazone (MET), finasteride (FIN), and dexamethasone (DEX) and an EOF marker (N,N-dimethylformamide, DMF). 

Ophthalmic (Restasis) Dexamethasone, Ophthalmic (AK-Dex Ophthalmic, Decadron Ophthalmic)... 

Dexamethasone base Aeroseb-Dex aerosol 0.01% Decadron cream 0.1% Low... 

Figure 4 Change in IOP of normotensive rabbits treated with 0.1% dexamethasone (Dex), 0.1% loteprednol etabonate (LE), and vehicle (50% w/w 2-hydroxypropyl- 3-cyclo-dextrin water solution). Twelve rabbits were investigated in crossover experiments drugs were administered in one eye (100 pL) every hour during the 8-h periods marked on the graph. (Data from Ref. 43 represent mean SE both for treated (T) and control (C) eyes.)...

Figure 4 X-ray structure of the GR LBD/Dex/TIF2 complex. Two 90-degree views are shown. The bulk of the LBD is shown in yellow with p strands in pink. The bound TIF2 peptide is in purple. Regions of the LBD that play major roles in TIF2 binding are shown in red (the AF-2 helix = helix 12) and blue. The bound dexamethasone molecule is in space-filling representation with carbon, oxygen, and hydrogen colored in green, red, and white, respectively. Reprinted from Reference (69) with permission from Elsevier.

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