Development of organophosphorus and carbamate insecticides

Interesting is the strong effect of monofluorophosphoric acid alkyl ester on the human organism. The vapours of the compounds smell pleasant and aromatic. However, just a few minutes after breathing there is a strong pressure against the head, connected 

Amiton-methyl C2H50 M /CH2 p—sch2ch2n C2H50 CH3 O II OCNHCH3 / 

Note The half-life may be calculated from the following formula t1/2 = ln2/k+3 

Source Most of the data are taken from Aldridge, W.N. and Reiner, E. 1972. Enzyme Inhibitors as Substrates Interactions of Esterases with Esters of Organophosphorus and Carbamic Acids, Vol. XVI. North-Holland Pub. Co., Amsterdam. 328 pp. 

Their work was not much noticed in Germany, but in England the work with the phosphofluorin was continued and led to DFP and other nerve gases. In Germany the cyano-compounds were studied by G. Schrader, who synthesized the nerve gas and insecticide tabun. 

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