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Development for Displacement Chromatography

Methods development for displacement chromatography has been previously described for a Langmuirian system using a graphical approach which employs the adsorption isotherms for the displacer and the various components [Pg.393]

The steric mass action (SMA) model has been shown to successfully predict nonlinear, multicomponent behavior in ion-exchange systems over a range of mobile phase salt concentrations.71-75 It has also been widely employed as a methods development tool for displacement separations.42,45,50 In this section, we will describe several graphical techniques derived this theory which can facilitate methods development in ion-exchange displacement systems. [Pg.394]

Isocratic elution under linear conditions at various mobile phase salt concentrations can be employed to determine v and K26 by the following expression  [Pg.394]

Linear gradient experiments can also be employed to determine K and v.52 Equation (3) relates a solute retention volume (Vg) to initial and final carrier salt concentrations (x xf), the gradient volume (Vg), the column [Pg.394]

This expression can be employed with two or more gradient experiments to determine v and K (using a least-squares fit). The gradient technique is better suited for simultaneously determining parameters for several components of a complex mixture. [Pg.395]


See other pages where Development for Displacement Chromatography is mentioned: [Pg.379]    [Pg.393]   


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