Development brain microvasculature

Nico, B., Quondamatteo, F., Ribatti, D., Bertossi, M., Russo, G., Herken, R., Roncali, L. Ultrastructural localization of lectin binding sites in the developing brain microvasculature. Anat. Embryol, 1998, 197, 305-315. 

Small and large punctate deposits are found, which disappear when the brain matures. Two other forms, sheath laminin and somal laminin, reduce in intensity but persist throughout adult life. Each has a unique spatial and temporal distribution. Small puncta appear first in development and disappear after fibre pathways have formed sheath laminin is associated with the microvasculature, the ependyma, the choroid plexus and the surface of the brain. Somal laminin, the last appearing, is found associated mainly with the cell body of neurons and is correlated with the appearance of compacting brain nuclei. 

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