Deuterium labelling carbocyclizations

Much recent research in this area has been driven by the need for radiolabeled quinoline-based pharmaceuticals for use in pharmacokinetic and mechanistic studies. The classical method for the synthesis of 8-deuterioquinolines is by hydrogen exchange of a quinoline precursor at the carbocyclic ring using deuteriosulfuric acid at high temperature. This method has been applied to the conversion of 4,7-dichloroquinoline to 8-deuterio-4,7-dichloroquinoline - a compound used in the synthesis of deuterium-labeled ferrochloroquine <1998JLCR911>. 

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