Determining Common Haplotypes

CLINICAL EXAMPLE OF HAPLOTYPES COMPOSED OF COMMON SNPs 

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Allotypic markers for human yl. y2, y3, a2 and e heavy chains have been defined as Glm, G2m, G3m, A2m and Em (WHO meeting, 1976 [172]). The subclass heavy chain allotypes Glm, G2m, G3m and A2m are normally inherited in specific combinations. Lefranc et al. (1979) [173] determined five major and four minor Gm-Am haplotypes in Tunisians and found different common haplotypes in Caucasoids and Negroids. Protein sequence comparisons demonstrate that there are only two amino acid differences between the G3m (b) and G3m (a) allotypes [155], Restriction length polymorphism has been found for the Ca2 gene [174] thus, independent identification of the A2m allelomorphs, which were previously distinguishable only by serology, has been established. 

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