Determination of Metoclopramide Hydrochloride by Using Europium Doped in TEOS Matrix

2 Determination of Metoclopramide Hydrochloride by Using Europium Doped in TEOS Matrix 

The Metoclopramide hydrochloride concentration was determined by the optical sensor europium doped in the sol-gel matrix. The absorption and emission spectra of Metoclopramide hydrochloride and Europium were measured in sol-gel matrix. The method depends on the enhancement of the intensity of the emission spectrum of Eu doped in sol-gel especially at 617 nm band. The mechanism depends on the energy transfer from triplet energy state of Metoclopramide hydrochloride to the excited energy state of Eu. In comparison with other spectrofluorimetric techniques, this method is simple, relatively interference free from coexisting substances and can successfully be applied to the determination of Metoclopramide hydrochloride in pharmaceutical preparations and in serum samples the data are summarized in Table 14.3 [53]. 

3 Nano-Optical Sensor for Chlorzoxazone and Ibuprofen Determination 

4 Nano-Optical Sensor for Norfloxacin and Gatifloxacin Determination 

The simultaneous and pH-assisted spectrofluorimetric determination of Norfloxacin (NFLX) and Gatifloxacin (GFLX) in the same sample in pharmaceutical preparations was developed. The method implies the formation of coordination complexes between Tb and Eu + and NFLX or GFLX in sol-gel matrix. The luminescence intensity of Tb and Eu + for these complexes in their mixtures is quite sensitive to two variant sets of pH and thus a dual-controlled luminescence is achieved and a reversible on/off switchable emission of one system was observed by timing its optimal values of 

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