Determination of copovidone in preparations

The detection reactions for copovidone given in Section 4.3.1.1 can be used to detect this copolymer in most pharmaceutical preparations. Should these provide no clear results, the separation scheme shown in Fig. 106 can be used to detect copovidone in solid dosage forms, e.g. tablets, granules, capsules and coated tablets. 

The detection and differentiation of povidone and copovidone obtained in Fraction A I in Fig. 106 is best carried out by thin layer chromatography on silica gel or paper. A suitable eluent is a mixture of 6 parts n-propanol and 4 parts 2N ammonia solution by volume, with which copovidone gives a higher Rf value than povidone (see Section 4.3.1.1). 

Sephadex is a registered trademark of Amersham Biosciences AB, Uppsala, Sweden 

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