Detectors potentially novel, selective

A review is provided of some of the latest advances in new and potentially novel, selective detectors for high performance liquid chromatography and flow injection analysis. 

The requirements for a potentially novel, selective detector in HPLC are several. Including 1) high sensitivity for many classes of analytes, perhaps into the low ppb range or below 2) high degree of selectivity in responses as dictated by many experimental variables ... 

Table I. Ideal Requirements for New and Potentially Novel, Selective Detectors in HPLC or FIA...

We are going to consider in this chapter a very select group of new and potentially novel detectors, all of which provide for greater selectivity in their responses than UV-VIS, FL, and/or EC. Our choice of which detectors to discuss and consider here has been based, in part, on how we perceive the current trends in detector development and application. It has also been based on our own biased and personal interests, as dictated by our own recent research and development results with these very same detectors. 

We have tried to depict some of the more recent advances In the development of new and potentially novel sensitive and selective detectors of use in HPLC and/or FIA. Our efforts and descriptions have been. 

Detectors with Enhanced Gas Sensitivity. One frequent complaint regarding the use of potentiometric gas and ion-selective membrane electrodes for analytical purposes is lack of precision owing to the logarithmic response of such devices. Thus, uncertainty in measured potentials of ilmV will result in i-4% precision for sensors with slopes of 5 9 mV/decade and —8% for those devices based on response to divalent ions (e.g., the above sulfite and SO2 gas sensors). One novel approach suggested in the literature for enhancing response slopes of potentiometric sensors is to use several membrane electrode cells in series (28, 29). This arrangement results in response... 

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