Detector-oriented acylation reactions

Hydroxyls primary and secondary amines amides thiols 

Although these derivatives all show enhanced responses in the ECD, more than one mechanism of electron capture has been described [2], and an understanding of these mechanisms may help in choosing the best 

Low detector temperatures apparently encourage the attachment process and high detector temperatures the dissociative process. The presence of molecules capable of either process will diminish the electron flux within the detector and consequently the standing current, and it is this reduction in the standing current which is amplified and measured to produce the detector signal. For practical purposes it is, however, enough to know that the sensitivity of detection increases in the order  

Other detectors besides the BCD may lead to the design of detector-oriented derivatization schemes, particularly where, as with the BCD, they improve the sensitivity or specificity of detection. One of these is the thermionic nitrogen/phosphorus detector (NPD), for which specific derivatives have been proposed, either in the nitrogen mode [5-8] or in the phosphorus mode [9,10]. More recently, the availability of the electrochemical detector has occasioned the application of specific derivatives such as the 0-acetylsalicyloyl derivatives for the HPLC of amines [11]. 

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