Detection of Ewings Sarcoma and Primitive Neuroectodermal Tumor

2 Molecular Detection of Ewing s Sarcoma and Primitive Neuroectodermal Tumor 

Other members of the TET family of RNA-binding proteins are the homologous FUS (TLS) and the TAFu 68 (RBP56) genes. These genes are the fusion partners in other translocations associated with other malignancies. 

The following genes of the ETS gene family are found to be the fusion partner of the EWS gene associated with Ewing s sarcoma and PNET family  

The ERG gene is also described as a fusion partner of the TEL gene, a homologous 

Recently rare cases of the primitive neuroectodermal tumors were described in association with translocations involving other members of TET family homologous to the EWS gene such as the EUS gene at 16pll and one of the members of the ETS gene family. 

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