Detection based on Au-NPs acidic or electrochemical dissolving

This detection procedure is based on the oxidative dissolution of the Au-NPs bound to DNA into aqueous Au ions followed by their electrochemical sensing. Chemical dissolution of the Au-NP tags has been mainly carried out with a HBr/Br2 solution, this step being followed by accumulation and stripping analysis of the resulting Au[lll) ions. Due to the high toxicity of the HBr/Br2 solution, other oxidation methods have been also employed. [Pg.124]

Analyte Modified Electrode Substrate Detection Technique Detection Limit Reference [Pg.125]

DNA synthetic strands Silicon wafer nanogap Current-voltage measurement - 53 [Pg.125]

Breast cancer-associated BRCA-1 mutant DNA AuE Chronocoulometiy [Ru(NH3)6] -fM 56 [Pg.125]

ASV anodic stripping voltammetry ATP adenosine triphosphate AuE gold electrode CV cyclic voltammetry DPV dififerential pulse voltammetry DPASV differential pulse adsorptive stripping voltammetry GCE assy carbon electrode MFE, mercury film electrode NPGE nanoporous gold electrode SPE screen-printed electrode. [Pg.125]