Dess-Martin procedure

Secondary alcohols are easily oxidized to give ketones. For a sensitive or costly alcohol, the Dess-Martin procedure is often used because the reaction is nonacidic and occurs at lower temperatures. For a large-scale oxidation, however, an inexpensive reagent such as Na2Cr207 in aqueous acetic acid might be used. 

T. Hervot, A. Leverot, B. Lesgent, J. N. Philippot, M. Martin, F. Schaeffer, and G. Wolsfelt. Cementing technology and procedures. Editions Techniq, Paris, France, Total, Gaz De France, Inst Francais Du Petrole, 1993. 

Fig. 17. Maximum anodic electrochemical current as a function of titanium content of samples synthesized by the classical method [TS-1(1) to TS-1 (4)] and by the modified procedure of Thangaraj el at. [TS-1 (5) to TS-1 (7)]. (From de Castro-Martins el al., Zeolites, 14, 1994, pp. 130-136. Reprinted with permission from the Publisher.)...

Normally, odd-numbered fatty acids are used as internal standards. While the use of internal standards ensures the correctness of the extraction procedure, it does not guarantee the completeness of extraction for different fatty acids. Due to this reason, a comparison between the methods is essential to truly determine the efficacy of extraction. Chavarri et al. (1997) compared two sample preparation procedures. The first method was the direct method developed by de Jong and Badings (1990), described above. The second method involved saponification with TMAH as described by Martin-Hemandez et al. (1988) and the formation of methyl esters in the injector prior to analysis. The authors found that separation of the FFAs from the triglycerides prior to derivatization improved the analysis. Another comparative study by Ardo and Polychroniadou (1999) reported that the saponification method described above (Martin-Hernandez et al., 1988) was found suitable for both low and high FFA levels in cheese. 

We will concentrate on Gaussian-type and CBS methods, because these have been the most widely-used and have thus accumulated an archive of results, are the most accessible, and because several versions of them are available. However, there are other high-accuracy multistep methods, such as the Weizmann procedures of Martin and de Oliveira, W1 and W2 [188], and of Boese et al., W3 and W4 [189], which like the CBS methods are based on basis set extrapolation. W1 and W2 have a mean absolute deviation of about 1 kJ mol 1 (not 1 kcal mol-1), and incorporate relativistic effects, and W2 has no empirical parameters, unlike the Gaussian and CBS methods. W3 and W4 methods have similar errors to W1 and W2, and the authors speculate on the reasons for the obstinate 0.1 kcal/mol barrier . These very accurate methods are still limited molecules of about or less than the reach of CBS-APNO. 

One might, given this previously described technique, take on this procedure. Then, perhaps, one might unite with the liberation achieved by Louis-Claude de Saint-Martin, which a seer of that period exclaimed in contemplating him from afar Now he has thrown the world behind him... ... 

Andreu, E. J., Martin de Llano, J. 1., Moreno, L, and Knecht, E. (1998) A rapid procedure suitable to assess quantitatively the endocytosis of colloidal gold and its conjugates in cultured cells. J. Histochem. Cytochem., 46, 1199-201. 

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