Desoxyadenosine

Desoxyadenosine oligonucleotides la 76 Desoxycholic acid la 334 11-Desoxycorticosterone la 221 lb 346 Detection, group-specific la 4,7 -, substance specific la 4,7 Detection of lipqjhilic substances la 43 -, biological-physiologically la4,6,7, 9,109... 

The reaction of 3 -amino-3 -desoxyadenosine 133 with thiophosphoryl chloride alTorded3, 5 -cyclothionophosphonate derivative 134 asamixture of P-diastereomcrs, which were separated by chromatography (Scheme 39) [70], The P-N bond cleavage,... 

For the first time, an enzyme able to create a carbon-fluorine bond has been isolated from Streptomyces cattleya. This enzyme has been characterized and then named fluorinase. In the presence of fluoride ions, this enzyme catalyzes the conversion of 5-adenosyl methionine into 5 -fluoro-5 desoxyadenosine (Figure 4.3). ... 

However, further evidences support the AA hypothesis. The presence of 7(desoxyadenosin-NCyl) aris-tolactam IDNA adducts (dA-AAl) was demonstrated in renal tissue samples obtained from five patients with... 

Halogenated ribonucleotides,8 Ribonucleosides can be converted conveniently into 5 -chlorinated and 5 -brominated ribonucleosides by reaction with either tliionyl chloride or thionyl bromide in combination with HMPT. For example, 5 -chloro-5 -desoxycytidine (1) and 5 -bromo-5 -desoxyadenosine (2) have been prepared in satisfactory yields in this way. 

Preparation of sulfides The reaction of the nucleoside adenosine (1.1 mmole) with dimethyl disulfide (10 mmole) and tri-n-butylphosphine (10 mmole) in DMF at 25° gives 5 -S-methylthio-5 -desoxyadenosine (2) in 73% yield. The reaction is general for desoxynucleosides and disulfides. This reaction... 

This enzyme occurs in many sources and has been purified from calf intestinal mucosa - and from AspergiUus Oryzae. Ammonia is removed from adenosine and also from desoxyadenosine. 

Charubala, R, Bannwarth, W., and Pfleiderer, W. (1980) Nucleotide, XII Synthese und Eigenschaften von Trinucleosiddiphosphaten mit Thymidin, 2 -Desoxyadenosin und l-(2 Desoxy-alpha-sowie l-(2 -Desoxy- l-D-ribo-furanosyO-lumazinen als Bausteine Liebigs Ann. Chem. 65-79. 

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