Desirability function, micellar

Reverse micellar extraction (RME) is another attractive LLE method for DSP of biological products, as many biochemicals including amino acids, proteins, enzymes, and nucleic acids can be solubilized within and recovered from such solutions without loss of native function/activity. In addition, these systems offer low interfacial tension, ease of scale-up, and continuous operation. RME offers a number of unique, desirable features in comparison with ATPE, which has been extensively studied ... 

The derivation of these different retention equations is important in several respects. First, they allow for calculation of micelle-solute binding constants, parameters which are important in many areas of micellar kinetics or chemistry. There have been several reports in the literature demonstrating this chromatographic approach for determination of micelle - solute binding constants (1,8,104,105). More importantly, they allow for prediction of retention behavior as a function of surfactant concentration (or of pH at constant micelle concentration), provided that the micelle - solute binding constant (or solute ionization constant) is known (which can be determined spectroscopically or from kinetic studies) (1,96,102). Consequently, the theory allows the chromatographer to determine the optimum conditions required for a desired separation. 

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