Tolcapone Desipramine

Entacapone and imipramine did not interact adversely in a single-dose study. Similarly, tolcapone and desipramine did not interact adversely. Nevertheless, the manufacturers of entacapone and tolcapone recommend caution if they are used with tricyclic antidepressants or other drugs that inhibit noradrenaline (norepinephrine) uptake, such as maprotiline or venlafaxine. 

In one study, healthy subjects were given desipramine 25 mg three times daily for 3 days then 50 mg three times daily for 10 days. For the last 5 days they were also given levodopa/carbidopa 100/25 mg three times daily and either a placebo or tolcapone 200 mg three times daily. The addition of tolcapone to combined treatment with levodopa/carbidopa and desipramine did not lead to any changes in haemodynamics or catecholamine levels, nor to any changes in desipramine pharmacokinetics. ... 

In these pharmacological studies, no important interaction between enta-capone and imipramine or between tolcapone and desipramine was detected. Nevertheless, the manufacturer of entacapone says there is limited clinical experience of the use of entacapone with tricyclic antidepressants, and they therefore recommend caution. Similarly, the manufacturers of tolcapone suggest that caution should be exercised with desipramine and any drugs that are potent noradrenaline (norepinephrine) uptake inhibitors such as maprotiUne and venlafaxine. ... 

Jorga KM, Fotteler B, Modi M, Rabbia M. Effect of tolcapone on die haemod3Hiamic effects and tolerability of desipramine. Eur Neurol (2000) 44, 94-103. 

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See also in sourсe #XX -- [ ]

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