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Design of Ion Channel Focused Libraries Chemical Genomics

We proposed several mutations to the Kvl.5 channel to validate our model. Docking of our inhibitors in the Kvl.5 binding site revealed Thr477 as very important for binding. Indeed, mutation of Thr477 to serine left the Kvl.5 channel fully functional, but the activity of all four types of Kvl.5 inhibitors significantly decreased [50], [Pg.233]

Design of Ion Channel Focused Libraries Chemical Genomics [Pg.233]

Design of Ion Channel Focused Libraries Chemical Genomics I 235... [Pg.235]

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Library design focusing