Design for Multiple Objectives and Targets Simultaneously

In the Piccolo method, the objective function combines all possible penalty functions in a weighted fashion  

Ideally, when ligand-based or structure-based models are developed for all members of a gene family, the validated models can be used as part of the multiobjective function in a comprehensive chemical library design environment. Like other factors discussed earlier, the predicted activities can be used in the weighted objective function. Compound library design or virtual screening can be achieved by optimizing the total objective function. 

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