General Desensitization

Agonist-specific desensitization, generally termed homologous desensitization, is associated with agonist-dependent GRK phosphorylation. Originally characterized in the case of rho-dopsin, it was later found to be common among GPCRs. 

Desensitization. Generally transient state of specific nonreactivity in previously sensitized individual, resulting from repeated antigen exposures. 

Desensitization General model based on receptor desensitization Internalization Model for cAMP signalling... 

In general, treatment of the asthma underlying NSAlDs sensitivity should follow standard asthma guidelines. This type of asthma is often severe and frequently high doses of inhaled corticosteroids and daily doses of oral corticosteroids are necessary. A special treatment option is a chronic desensitization to aspirin [8]. Desensitization and aspirin maintenance is routinely used in some centers for treatment of chronic rhinusinusitis with nasal polyposis. It is the only available procedure which allows AIA patients with ischemic heart disease to use aspirin. During the state of desensitization to aspirin, not only aspirin but almost all strong NSAIDs are tolerated, so desensitization and NSAID maintenance could be used for treatment of rheumatic disease or chronic pain syndromes. 

In a patient with a positive penicillin skin test or a history of immediate hypersensitivity to penicillin, vancomycin is the agent of choice. Vancomycin, however, kills S. aureus slowly and is generally regarded as inferior to penicillinase-resistant penicillins for MSSA. Penicillin-allergic patients who fail on vancomycin therapy should be considered for penicillin desensitization. 

A very important facet of the general subject of impact sensitivity is the artificial lowering-desensitization-of the impact sensitivity of certain explosives. If we accept Eq 8 as being at least qualitatively correct take Dm as a measure of impact sensitivity, then from Eqs (1), (8) (10) and the usual situation of Per Ou,... 

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