Dermatitis herpetiform

Sheskin J, Sagher F. Erupcion tipo dermatitis herpetiforme en enfermos del mal de Hansen tratados con talidomida. [Dermatitis herpetiformis-like eruption in patients with Hansen disease treated with thalidomide.] FontiUes (Alicante) 1968 7 229. 

Dapsone, a sulfone with chemical similarities to sulfapyridine, has been used for over 50 years. It is the most widely used drug for the treatment of of leprosy, and it is used for quinine-resistant Plasmodium falciparum medeLrieL. Dapsone is currently used for the primary treatment of dermatitis herpetiform, chronic bullous dermatosis and can be replaced by sulfapyridine in patients with intolerance to the sulfone... 

Dapsone, which was first proposed in 1941, possesses both bactericidal as weU as bacteriostatic activity with respect to Mycobacterium leprae and Mycobacterium tuberculosis. It is used to treat patients with herpetiform dermatitis. It is believed that the mechanism of its action consists of competitive inhibition of the enzyme dihydroprotease synthetase, which blocks synthesis of folic acid in microorganisms, allowing it to also be viewed as an analog of p-aminobenzoic acid. Synonyms of this drug are avosulfon, croysulfon and others. 

---