Derivatives of Organic Acids

Fig. 5.12. Gas chromatogram of TMS derivatives of organic acids. Peaks 1 = lactic 2 = (3-hydroxy-butyric 3 = fumaric 4 = succinic 5 = malic 6 = oxaloacetic 7 = a-ketoglutaric 8 = citric 9 = iso-citric acid. Conditions glass column, 12 ft. X 4 mm, 5% OV-22 on Gas-Chrom P (80-100 mesh) nitrogen flow-rate, 40-50 ml/min temperature programme, 2°C/min from 50°C. (Reproduced from Anal. Lett., 1 (1968) 713, by courtesy of M.G. Horning and Marcel Dekker.)...

Plasticizers Increase the workability, flexibility or Derivatives of organic acids such as adipic. 

Amides are thought of as derivatives of organic acids and ammonia, primary amines, or... 

The trifluoroethyl (CF3CH2—) derivative of organic acids and alcohols has been found to be useful for distinguishing carboxyl from primary hydroxyl from secondary hydroxyl functional groups by F nuclear magnetic resonance spectroscopy (Roller and Dorn, 1982). This derivative is formed under conditions shown in reaction (4) ... 

Basic beryllium derivatives of organic acids, synthesis 2... 

Plasticizers Increase the workabihty, flexibility or distensibility of polymer Derivatives of organic acids such as adipic, azelic, citric, phosphoric, phthahc, trimellitic acids... 

Derivatives of organic acids are also important for the production of polymers, detergents, dyestuffs, explosives, pesticides, insecticides, etc. Many occur in nature. 

A comprehensive collection of spectra from a number of sources of trimethylsilyl derivatives of organic acids of biological interest was compiled by Markey et al (1972) and subsequently included in a larger reference collection (Markey et al., 1974b) and in other library files (e.g. Mass Spectrometry Data Centre Collection, The University, Nottingham, England). In addition to spectra of trimethylsilyl (TMS) derivatives are spectra of free acids, methyl esters, methyl ester-trimethylsilyl ethers (hydroxy acids), and trimethylsilyl esters-trimethylsilyl ethers-methoximes (oxo acids or oxo hydroxy acids). 

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