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Dercitin

Dercitin (464) is a violet acridine alkaloid from a deepwater species of Dercitus with antitumour, antiviral and immunomodulatory properties in vitro [389] and with in vivo antitumour activity [390]. The structure was proposed on the basis of spectral properties. Cyclodercitin (465) was isolated as a minor alkaloid from a deepwater Dercitus species and three... [Pg.686]

Most of these compounds displayed very potent cytotoxic activity against several tumor cells. Dercitin (435) was also active in vivo, prolonging the life of P388-bearing mice with a T/C of 170 at 5 mg/Kg. Compound 435 inhibited both DNA and RNA synthesis, DNA polymerase and I/DNase nick translation, bound to calf thymus DNA, and relaxed supercoiled <()X174DNA [348]. The compounds also showed... [Pg.895]

Gunawardana, G. P., Koehn, F. E., Lee, A. Y., Clardy, J., He, H., and Faulkner, D. J., Pyridoacridine alkaloids from deep-water sponges of the family Pachastrellidae structure revision of dercitin and related compounds and correlation with kuanoniamines, J. Org. Chem., 57, 1523, 1992. [Pg.539]

Dercitine (sponge) Active against P388, HCT-8 cells — 144... [Pg.36]

Dercitine (sponge) Inhibition of herpes simplex virus, murine corona virus 1-5 144... [Pg.80]

See other pages where Dercitin is mentioned: [Pg.190]    [Pg.71]    [Pg.93]    [Pg.236]    [Pg.687]    [Pg.687]    [Pg.893]    [Pg.894]    [Pg.894]    [Pg.71]    [Pg.528]    [Pg.532]    [Pg.539]    [Pg.1164]    [Pg.116]    [Pg.71]    [Pg.115]    [Pg.116]    [Pg.116]    [Pg.119]    [Pg.269]    [Pg.270]    [Pg.391]    [Pg.393]    [Pg.115]    [Pg.116]    [Pg.116]    [Pg.119]    [Pg.530]    [Pg.566]    [Pg.69]    [Pg.71]   
See also in sourсe #XX -- [ Pg.686 ]

See also in sourсe #XX -- [ Pg.893 , Pg.894 ]

See also in sourсe #XX -- [ Pg.71 ]

See also in sourсe #XX -- [ Pg.70 , Pg.115 ]

See also in sourсe #XX -- [ Pg.25 , Pg.28 , Pg.686 , Pg.893 , Pg.894 ]

See also in sourсe #XX -- [ Pg.70 , Pg.115 ]



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Dercitin antiviral activity

Dercitin immunomodulatory properties

Dercitins

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