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Deprotection, selective protection methodologies

Titanium tetrakis(diethylamide) selectively adds to aldehydes in the presence of ketones and to the least hindered ketone in compounds containing more than one ketone. The protection is in situ, which thus avoids the usual protection/deprotection sequence. Selective aldol and Grignard additions are readily performed employing this protection methodology. ... [Pg.361]

An analogous methodology was used for the synthesis of selective ACE inhibitor quinapril. Condensation of 5-phenylaIanine with formaldehyde in the presence of sulfuric acid produced an intermediate imine, which was readily cyclized to for predominantly only one enantiomer of the tetrahydroisoquinoline core. Protection of carboxylic acid moiety was followed by acylation with the appropriate acid to form quinapril after deprotection. [Pg.518]

See other pages where Deprotection, selective protection methodologies is mentioned: [Pg.140]    [Pg.255]    [Pg.177]    [Pg.344]    [Pg.340]    [Pg.346]    [Pg.65]    [Pg.410]    [Pg.1243]    [Pg.83]    [Pg.288]    [Pg.135]    [Pg.126]    [Pg.110]    [Pg.133]    [Pg.142]    [Pg.240]    [Pg.484]    [Pg.155]    [Pg.161]    [Pg.57]    [Pg.34]    [Pg.285]    [Pg.314]    [Pg.19]    [Pg.105]    [Pg.388]    [Pg.1045]    [Pg.688]    [Pg.1707]    [Pg.2638]    [Pg.115]    [Pg.14]    [Pg.676]    [Pg.31]    [Pg.72]    [Pg.206]    [Pg.401]    [Pg.187]    [Pg.30]    [Pg.64]    [Pg.230]    [Pg.356]    [Pg.176]    [Pg.688]    [Pg.3605]   
See also in sourсe #XX -- [ Pg.70 , Pg.71 ]



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Protection -deprotection

Selective Deprotections

Selective deprotection

Selective protection

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