Deposition in the lungs of

Kliment, V. Similarity and dimensional analysis, evaluation of aerosol deposition in the lungs of laboratory animals and man. Folia Morphol. 21 59-64, 1973. 

Following inhalation exposure, about 20-35% of nickel deposited in the lungs of humans is absorbed into the bloodstream. Absorption from the respiratory tract is dependent on the solubility of the nickel compound, with higher urinary nickel observed in workers exposed to soluble nickel compounds (nickel chloride, nicke sulfate) than in those exposed to less-soluble nickel compounds (nickel oxide, nickel subsulfrde). Following oral exposure, about 27% of the nickel given to humans in drinking water was... 

Deposition in the lungs of 203Pb-labelled exhaust particles... 

Segal, R. A., Martonen, T. B., Kim, C. S., and Shearer, M. (2002), Computer simulations of particle deposition in the lungs of chronic obstructive pulmonary disease patients, Inhal. Toxicol., 14,705-720. 

Yamada H, Hashimoto H, Akiyama M, et al. 1997. Talc and amosite/crocidolite preferentially deposited in the lungs of nonoccupational female lung eaneer eases in urban areas of Japan. Environ Health Perspect 105 504-508. 

Small aerosol particles, 1-5 pm in diameter, have been condensation coated from a vapor of a fatty acid or paraffin wax. These particles have been shown to exhibit reduced dissolution rates in vitro, corresponding to reduced absorption rates following deposition in the lungs of Beagle dogs. 

The protective effects of liposome-entrapped superoxide dismutase and catalase have also been studied on bleomycin-induced collagen deposition in the lungs of mice (Ledwozyn, 1991). It has been suggested that liposomes might be good vectors for drugs in the treatment of bleomycin-induced fibrosis. 

The inhalation pathway is the major route for chemicals into the body. Gases and vapours can penetrate deep into the lungs where, as the penetration of particles is strongly dependent on size, the general rule being the finer (smaller) the further they penetrate. Deposition in the lungs of very fine (1-2/xm) particles is of greatest concern. The action of asbestos is well known. ... 

Table 7.7 Percentage deposition in the lung of environmental lead (Based on [10]).

Imokawa S, Sato A, Hayakawa H, et al. Tissue factor expression and fibrin deposition in the lungs of patients with idiopathic pulmonary fibrosis and systemic sclerosis. Am J Respir Crit Care Med 1997 156 631-636. 

Particulate matter can be generated from welding and deposited in the lungs of the worker. Proper ventilation is necessary to keep exposure levels as low as possible. A few of the metals that generate particulate matter are aluminum, iron oxide, and tin. 

Figure 3 E25 levels in the serum following a daily aerosol administration in the rat. Rats were exposed to an E25 aerosol generated by a Pari-IS-2 nebulizer for 30 min/day for 7 days in a nose-oiily inhalation chamber. 116 xg/kg of E25 deposited in the lungs of the rats per day. (From Ref. 20.)...

Vincent JH, Johnston WB, Jones AD, Johnston AM. Statie electrification of airborne asbestos a study of its causes, assessment and effects on deposition in the lungs of rats. Am Ind Hyg Assoc J 1981 42 711-721. 

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