Depolarisation-induced suppression

Cannabinoid involvement in Depolarisation-Induced Suppression of Inhibition... 

Recent findings imphcate apoptosis in neuronal degeneration after ischaemic brain injury in animal models of stroke (Mattson et al. 2000). Apoptotic cascades involve increased levels of intraceUular oxyradicals and calcimn induction of expression of proteins such as Par-4 (prostate apoptosis response-4), which act by promoting mitochondrial dysfunction and suppressing antiapoptotic mechanisms mitochondrial membrane depolarisation, calcium uptake, and release of factors (e.g. cytochrome c) that ultimately induce nuclear DNA condensation and fragmentation activation of cysteine proteases of the caspase family activation of transcription factors such as AP-1 that may induce expression of killer genes . 

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