2-Deoxyuridine-5 -carboxylic acid

Methyl-2 -deoxycytidine (437) and 3-methyl-2 -deoxyuridine (438) were isolated from the Swedish sponge Geodia baretti. Compound 437 exhibits strong contractile activity in the isolated guinea pig ileum assay, whereas 438 had no effect on contractions (356). Thymidine-5 -carboxylic acid (439) and 2 -deoxyuridine-5 -carboxylic acid (440), which were previously known only as synthetic products, were found in extracts of the ascidian Aplidium fuscum of the East Pyrenean coast (357). 

The monomers, (R)-(-)-uracil-l-yl-2,3-dihydrofliian la and (R)-(-)-2-thymin-l-yl-2,3-dihydrofuran Ib were synthesized according to Zemlicka s methods - which involved oxidation of 2-deoxyuridine and tlqmiidine followed by decarboxy dehydration of the resulting 2 -deoxyuridine-5 -carboxylic acid and thymidine-5 -carboxylic acid. 

Carboxylic acid [3180-30-1]. 2 -Deoxyuridine-5 -carboxylic acid QHioNjOg M 242.188... 

Deoxyuridine, Z-3 2 -Deoxy- j/-uridine, D-354 2 -Deoxyuridine, D-382 3 -Deoxyuridine, D-383 5 -Deoxyuridine, D-384 2 -Deoxyuridine-5 -carboxamide, D-382 2 -Deoxyuridine-5 -carboxylic acid, D-382 2"-Deoxy-5 -uridylic acid, D-382 2 -Deoxy-5-vinyluridine, V-21... 

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