Deoxythymidylic acid

Thymine is found only in DNA but not in RNA. Deoxythymidylic acid is formed by methylation of deoxyuridylic acid this may be an indication that ribonucleosides were present on the young Earth before the deoxynucleosides. 

Deoxytetracyclines, 24 595, 596 Deoxythymidylic acid (dTMP), folic acid and, 25 801... 

Thymine Deoxythymidme Deoxythymidylic acid Deoxythymidine monophosphate (dTMP) Deoxythymidine diphosphate (dTDP) Deoxythymidine triphosphate (dTTP)... 

Ito et al. [20] studied the mechanism to produce strand breakage by phosphorus photoabsorption using a dinucleotide as a sample, and revealed that even with photoabsorption by phosphorus strand breakage occurs through the destruction of deoxyribose of the 5 end, leaving adenine and 5 -AMP as products. Yamada et al. [21] used penta-deoxythymidylic acid (d(pT)5) as a sample, and analyzed the products quantitatively with on-resonance (2153 eV) and off-resonance (2147 eV) x-rays. They found that the distribution of the products was independent of the x-ray energy, and that the yields of the products were proportional to the absorption cross section of the sample. Unexpectedly, they could not find any evidence of Auger-specific products, neither qualitatively nor quantitatively. 

FIGURE 9.9 Th)unidylate s)mthase. Thymine is the pyrimidine base that occurs in thymidylic acid (th3mudylate). Th3miidylic acid (TMP) is the same as deoxythymidylic acid (dTMP), and both terms are in use. Thymine occurs in DNA but not in RNA. Conversely, uracil occurs in RNA but usually not in DNA. Th)unidylate synthase is a well-known folate-ifequiring enz)une. 

Figure 8.51. Methylation of deoxyuridylicacid forming deoxythymidylic acid.

Thymidylate synthetase is an important enzyme, which is responsible for the reductive methylation of deoxyuridylic acid (dUMP, 7) to deoxythymidylic acid (dTMP, 8). The methylation of the uracil moiety (present in RNA) to 5-methyl uracil (thymine, present in DNA) requires participation of a folic acid coenzyme, N, methylenetetrahydrofolate as a methyl donor. The functioning of thymidylate synthetase is coupled with the activity of DHF reductase. That is why this biochemical target is usually referred to as thymidylate synthetase/ DHF reductase. 

Ans. Name deoxythymidine monophosphate or deoxythymidylic acid abbreviation dTMP... 

Thymine T Thymidylic acid TMP Deoxythymidylic acid dTMP... 

Permutt, M. A., Biesbroeck, J., Chyn, R., Boime, I., Szczesna, E., and McWilliams, D., 1976, Isolation of a biologically active messenger RNA Preparation from fish pancreatic islets by oligo (2 -deoxythymidylic acid) affinity chromatography, in Polypeptide Hormones Molecular and Cellular Aspects, pp. 97-116, Ciba Found. Symp. 41, Elsevier/Excerpta Medica/North-Holland, Amsterdam. 

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